Apoptosis is a spontaneous process in regular cells after physiological and pathological stimuli. It is the autophagic cell death that is controlled by the gene in order to maintain a stable environment. Together with proliferation, it maintains the normal growth and development of the body and the stability of the internal environment. Apoptosis is not a passive process. It is an active process involving the activation, expression and, regulation of a series of genes. Therefore, if the cells that are supposed to be apoptotic do not have normal apoptosis, they are similar to the phenomenon of cancer cells. A protease called caspase (cysteinyl aspartate-specific protease) plays an important role in cell apoptosis. In recent years, a large number of studies have predicted the potential of Caspase as a target to treat related diseases caused by excessive apoptosis of cells. The study of small-molecule Caspase inhibitor is one of the important topics in the life science field.

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